1. Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601 China; 2. High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei 230031 China; 3. Science Island Branch of Graduate School University of Science and Technology of China Hefei 230026 China; 4. Heye Health Technology Co. Ltd Huzhou 313300 China
Abstract：Several studies have shown that magnetic fields have various effects on the blood glucose level and diabetic complications. This paper systematically compares and analyzes the effects of magnetic fields with different parameters on blood glucose, insulin levels, as well as diabetes complications in different biological systems. The results show that although the effects of magnetic fields on blood glucose and insulin levels are variable due to the diversity of magnetic parameters and biological samples examined, the magnetic fields usually have positive effects on diabetic wound healing and osteoarthropathy, indicating their promising clinical application potential. Although the mechanism of magnetic field affecting blood glucose has not been systematically explored, there are evidences showing that magnetic field may affect insulin levels by affecting cell membrane, membrane proteins and Ca2+ concentrations. This will not only help people to understand the effect of magnetic field on blood glucose regulation and diabetes, but also lay a foundation for the systematic investigations and potential application of magnetic field in the treatment of diabetes and its complications in the future.
冯传林, 郁彪, 方彦雯, 方志财, 张欣. 磁场影响血糖和糖尿病并发症研究进展[J]. 电工技术学报, 2021, 36(4): 693-704.
Feng Chuanlin, Yu Biao, Fang Yanwen, Fang Zhicai, Zhang Xin. Research Progress of the Effects of Magnetic Field on Blood Glucose and Diabetic Complications. Transactions of China Electrotechnical Society, 2021, 36(4): 693-704.
[1] 张欣, Yarema K, 许安. 稳态磁场的生物学效应[M]. 北京: 科学出版社, 2018. [2] Zhang Xin, Yarema K, Xu An.Biological effects of static magnetic fields[M]. Singapore: Springer, 2017. [3] Zhang Xin, Wang J F.Interdisciplinary research of magnetic fields and life sciences[M]. Beijing: Science Press, 2018. [4] Lefaucheur J P, Aleman A, Baeken C, et al.Evidence- based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018)[J]. Clinical Neurophysiology, 2020, 131(2): 474-528. [5] 李达, 许毅, 安建雄. 重复经颅磁刺激治疗专家共识[J]. 转化医学杂志, 2018, 7(1): 4-9. Li Da, Xu Yi, An Jianxiong.Chinese experts con- sensus on repetitive transcranial tagnetic stimulation[J]. Translational Medicine Journal, 2018, 7(1): 4-9. [6] Zhou Xiaoqing, Liu Shikun, Wang Yuexiang, et al.High-resolution transcranial electrical simulation for living mice based on magneto-acoustic effect[J]. Frontiers in Neuroscience, 2019, 13(1342): 1-12. [7] Wang Huiqin, ZhouXiaoqing, Cui Dong, et al. Comparative study of transcranial magneto-acoustic stimulation and transcranial ultrasound stimulation of motor cortex[J]. Frontiers in Behavioral Neuroence, 2019, 13(241): 1-10. [8] Assoc A D.Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2010, 33(S1): 62-69. [9] Kaul K, Tarr J M, Ahmad S I, et al.Introduction to diabetes mellitus[J]. Advances in Experimental Medicine and Biology, 2012, 771: 1-11. [10] Touitou Y, Djeridane Y, Lambrozo J, et al.Long-term (up to 20 years) effects of 50Hz magnetic field exposure on blood chemistry parameters in healthy men[J]. Clinical Biochemistry, 2012, 45(6): 425-428. [11] Gorczynska E, Wegrzynowicz R.Glucose-homeostasis in rats exposed to magnetic-fields[J]. Investigative Radiology, 1991, 26(12): 1095-1100. [12] Sihem C, Hafedh A, Mohsen S, et al.Effects of sub-acute exposure to magnetic field on blood hematological and biochemical parameters in female rats[J]. Turkish Journal of Hematology, 2006, 23(4): 182-187. [13] Chater S, Abdelmelek H, Pequignot J M, et al.Effects of sub-acute exposure to static magnetic field on hematologic and biochemical parameters in pregnant rats[J]. Electromagnetic Biology & Medicine, 2006, 25(3): 135-144. [14] Elferchichi M, Mercier J, Coisy-Quivy M, et al.Effects of exposure to a 128mT static magnetic field on glucose and lipid metabolism in serum and skeletal muscle of rats[J]. Archives of Medical Research, 2010, 41(5): 309-314. [15] Elferchichi M, Mercier J, Bourret A, et al.Is static magnetic field exposure a new model of metabolic alteration? comparison with Zucker rats[J]. Inter- national Journal of Radiation Biology, 2011, 87(5): 483-490. [16] Lahbib A, Elferchichi M, Ghodbane S, et al.Time- dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat[J]. General Physiology and Biophysics, 2010, 29(4): 390-395. [17] Lahbib A, Ghodbane S, Maaroufi K, et al.Vitamin D supplementation ameliorates hypoinsulinemia and hyperglycemia in static magnetic field-exposed rat[J]. Archives of Environmental & Occupational Health, 2015, 70(3): 142-146. [18] Laitl-Kobierska A, Cieslar G, Sieron A, et al.Influence of alternating extremely low frequency ELF magnetic field on structure and function of pancreas in rats[J]. Bioelectromagnetics, 2002, 23(1): 49-58. [19] Ocal I, Kalkan T, Gunay I.Effects of alternating magnetic field on the metabolism of the healthy and diabetic organisms[J]. Brazilian Archives of Biology and Technology, 2008, 51(3): 523-530. [20] Hashish A H, El-Missiry M A, Abdelkader H I, et al. Assessment of biological changes of continuous whole body exposure to static magnetic field and extremely low frequency electromagnetic fields in mice[J]. Ecotoxicology & Environmental Safety, 2008, 71(3): 895-902. [21] 韩丽莎, 王芳. 旋磁场对糖代谢影响的研究[J]. 中华理疗杂志, 1997, 20(4): 231-232. Han Lisha, Wang Fang.Effect of rotating magnetic field on glucose metabolism[J]. Chinese Journal of Physical Therapy, 1997, 20(4): 231-232. [22] Abbasi M, Nakhjavani M, Hamidi S, et al.Constant magnetic field of 50mT does not affect weight gain and blood glucose level in BALB/c mice[J]. Medical Science Monitor, 2007, 13(7): 151-154. [23] 郭毅敏, 汪天赐, 蔡婧, 等. 正弦波交变电磁场对2型糖尿病皮肤软组织创伤愈合修复的研究[J]. 成都医学院学报, 2020, 15(1): 13-18. Guo Yimin, Wang Tianci, Cai Jing, et al.Study on the effect of sinusoidal alternating electromagnetic fields on the wound healing and repair of soft tissues in patients with type 2 diabetes mellitus[J]. Journal of Chengdu Medical College, 2020, 15(1): 13-18. [24] Hayek A, Guardian C, Guardian J, et al.Homo- geneous magnetic fields influence pancreatic islet function in vitro[J]. Biochemical & Biophysical Research Communications, 1984, 122(1): 191-196. [25] Jolley W B, Hinshaw D B, Knierim K, et al.Magnetic field effects on calcium efflux and insulin secretion in isolated rabbit islets of Langerhans[J]. Bioelectro- magnetics, 1983, 4(1): 103-106. [26] Sakurai T, Koyama S, Komatsubara Y, et al.Decrease in glucose-stimulated insulin secretion following expo- sure to magnetic fields[J]. Biochemical & Biophysical Research Communications, 2005, 332(1): 28-32. [27] Paras S D, Gajanin R B, Manojlovi M L, et al.Impact of high-frequency electromagnetic fields on secretion and structure of pancreas in rats[C]//European Medical and Biological Engineering Confernce Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, Tampere, Finland, 2017: 711-714. [28] Sakurai T, Yoshimoto M, Koyama S, et al.Exposure to extremely low frequency magnetic fields affects insulin-secreting cells[J]. Bioelectromagnetics, 2008, 29(2): 118-124. [29] Sakurai T, Terashima S, Miyakoshi J.Effects of strong static magnetic fields used in magnetic resonance imaging on insulin-secreting cells[J]. Bioelectromagnetics, 2009, 30(1): 1-8. [30] Mao Libin, Guo Zhixia, Wang Huiqin, et al.Exposure to static magnetic fields affects insulin secretion in ins cells[J]. Lecture Notes in Electrical Engineering, 2015, 333: 643-648. [31] Mao Libin, Wang Huiqin, Ma Fenghui, et al.Exposure to static magnetic fields increases insulin secretion in rat INS-1 cells by activating the transcription of the insulin gene and up-regulating the expression of vesicle-secreted proteins[J]. International Journal of Radiation Biology, 2017, 93(8): 831-840. [32] Boulton A J, Gries F A, Jervell J A.Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy[J]. Diabetic Medicine, 1998, 15(6): 508-514. [33] Said G.Diabetic neuropathy-a review[J]. Nature Clinical Practice Neurology, 2007, 3(6): 331-340. [34] Yagihashi S, Yamagishi S, Wada R.Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms[J]. Diabetes Research & Clinical Practice, 2007, 77(S1): 184-189. [35] Obrosova I G.Diabetes and the peripheral nerve[J]. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2009, 1792(10): 931-940. [36] Weintraub M I, Wolfe G I, Barohn R A, et al.Static magnetic field therapy for symptomatic diabetic neuropathy: a randomized, double-blind, placebo- controlled trial[J]. Archives of Physical Medicine and Rehabilitation, 2003, 84(5): 736-746. [37] Musaev A V, Guseinova S G, Imamverdieva S S.The use of pulsed electromagnetic fields with complex modulation in the treatment of patients with diabetic polyneuropathy[J]. Neuroence & Behavioral Physiology, 2003, 33(8): 745-752. [38] Wrobel M P, Szymborska-Kajanek A, Wystrychowski G, et al.Impact of low frequency pulsed magnetic fields on pain intensity, quality of life and sleep disturbances in patients with painful diabetic poly- neuropathy[J]. Diabetes & Metabolism, 2008, 34(4 Pt 1): 349-354. [39] Weintraub M I, Herrmann D N, Smith A G, et al.Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair: a randomized controlled trial[J]. Archives of Physical Medicine and Rehabilitation, 2009, 90(7): 1102-1109. [40] Lei Tao, Jing Da, Xie Kangning, et al.Therapeutic effects of 15Hz pulsed electromagnetic field on diabetic peripheral neuropathy in streptozotocin- treated rats[J]. PLoS One, 2013, 8(4): 1-9. [41] Mert T, Gisi G, Celik A, et al.Frequency-dependent effects of sequenced pulsed magnetic field on experimental diabetic neuropathy[J]. International Journal of Radiation Biology, 2015, 91(10): 833-842. [42] Mert T, Sahin E, Yaman S, et al.Pulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetes[J]. Archives of Physiology and Biochemistry, 2020, https://doi.org/10.1080/13813455. 2020.1788098. [43] Motley T A, Gilligan A M, Lange D L, et al.Cost- effectiveness of clostridial collagenase ointment on wound closure in patients with diabetic foot ulcers: economic analysis of results from a multicenter, randomized, open-label trial[J]. Journal of Foot and Ankle Research, 2016, 9(1): 1-7. [44] Jing Da, Shen Guanghao, Cai Jing, et al.Effects of 180mT static magnetic fields on diabetic wound healing in rats[J]. Bioelectromagnetics, 2010, 31(8): 640-648. [45] 孙涛, 罗二平, 申广浩, 等. 静磁场对糖尿病大鼠表皮创伤的抑制作用[J]. 医疗卫生装备, 2014, 35(4): 4-6. Sun Tao, Luo Erping, Shen Guanghao, et al.Inhibitive effects of static magnetic field on wound healing in diabetes rat[J]. Chinese Medical Equipment Journal, 2014, 35(4): 4-6. [46] 雷霆, 孟昕珂, 魏海梁, 等. 磁疗对糖尿病足溃疡大鼠模型创面愈合的影响[J]. 世界中西医结合杂志, 2020, 15(4): 638-641. Lei Ting, Meng Xinke, Wei Hailiang, et al.Effect of magnet therapy on wound healing in rat models with diabetic foot ulcer: an experimental study[J]. Word Journal of Integrated Traditional and Western Medicine, 2020, 15(4): 638-641. [47] Zhao Jing, Li Yongguo, Deng Kaiqin, et al.Therapeutic effects of static magnetic field on wound healing in diabetic rats[J]. Journal of Diabetes Research, 2017: 6305370. [48] 聂志勇, 邢柏春, 李耀明, 等. 300mT恒磁场对于糖尿病大鼠创伤愈合的影响[J]. 现代生物医学进展, 2013, 13(20): 3801-3803. Lie Zhiyong, Xing Bochun, Li Yaoming, et al.Effects of 300mT static magnetic fields on diabetic wound healing in rats[J]. Progress in Modern Biomedicine, 2013, 13(20): 3801-3803. [49] Shang Wenlong, Chen Guilin, LiYinxiu, et al. Static magnetic field accelerates diabetic wound healing by facilitating resolution of inflammation[J]. Journal of Diabetes Research, 2019(2): 1-11. [50] 刘丹, 汪天赐, 景达, 等. 中等强度的全身性稳恒磁场暴露对于2型糖尿病软组织创伤愈合修复的实验研究[J]. 海南医学院学报, 2019, 25(19): 1441-1446. Liu Dan, Wang Tianci, Jing Da, et al.Repairing effects of moderate-intensity static magnetic fields on wound healing of type 2 diabetic soft tissue[J]. Journal of Hainan Medical University, 2019, 25(19): 1441-1446. [51] Callaghan M J, Chang E I, Seiser N, et al.Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release[J]. Plastic & Reconstructive Surgery, 2008, 121(1): 130-141. [52] Goudarzi I, Hajizadeh S, Salmani M E, et al.Pulsed electromagnetic fields accelerate wound healing in the skin of diabetic rats[J]. Bioelectromagnetics, 2010, 31(4): 318-323. [53] Cheing G L, Li Xiaohui, Huang Lin, et al.Pulsed electro-magnetic fields (PEMF) promote early wound healing and myofibroblast proliferation in diabetic rats[J]. Bioelectromagnetics, 2014, 35(3): 161-169. [54] Choi M C, Cheung K K, Li Xiaohui, et al.Pulsed electromagnetic field (PEMF) promotes collagen fibre deposition associated with increased myofibroblast population in the early healing phase of diabetic wound[J]. Archives of Dermatological Research, 2016, 308(1): 21-29. [55] Choi H M C, Cheing A K K, Ng G Y F, et al. Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing[J]. PLoS One, 2018, 13(11): 1-12. [56] Krakauer J C, Mckenna M J, Buderer N F, et al.Bone loss and bone turnover in diabetes[J]. Diabetes, 1995, 44(7): 775-782. [57] Botolin S, Mccabe L R.Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice[J]. Endocrinology, 2007, 148(1): 198-205. [58] Heath H, Melton L J, Chu Chupin.Diabetes mellitus and risk of skeletal fracture[J]. New England Journal of Medicine, 1980, 303(10): 567-570. [59] Macey L R, Kana S M, Jingushi S, et al.Defects of early fracture-healing in experimental diabetes[J]. The Journal of Bone and Joint Surgery, 1989, 71(5): 722-733. [60] Hofbauer L C, Brueck C C, Singh S K, et al.Osteoporosis in patients with diabetes mellitus[J]. Journal of Bone & Mineral Research, 2007, 22(9): 1317-1328. [61] Gulcelik N E, Bayraktar M, Caglar O, et al.Mortality after hip fracture in diabetic patients[J]. Experimental and Clinical Endocrinology & Diabetes, 2011, 119(7): 414-418. [62] Hanft J R, Landsman A, Surprenant M S, et al.The role of combined magnetic field (CMF) bone growth stimulator as an adjunct in the treatment of neuroarthropathy Charcot joint[J]. Diabetes, 1998, 37(6): 510-515. [63] Zhang Hao, Gan Lu, Zhu Xiaoquan, et al.Moderate- intensity 4mT static magnetic fields prevent bone architectural deterioration and strength reduction by stimulating bone formation in streptozotocin-treated diabetic rats[J]. Bone, 2018, 107: 36-44. [64] Jing Da, Cai Jing, Shen Guanghao, et al.The preventive effects of pulsed electromagnetic fields on diabetic bone loss in streptozotocin-treated rats[J]. Osteoporosis International, 2011, 22(6): 1885-1895. [65] Li Jianjun, Zeng Zhaobin, Zhao Yantao, et al.Effects of low-intensity pulsed electromagnetic fields on bone microarchitecture, mechanical strength and bone turnover in type 2 diabetic db/db mice[J]. Scientific Reports, 2017, 7(1): 1-13. [66] Cai Jing, Li W, Sun Tingyi, et al.Pulsed electro- magnetic fields preserve bone architecture and mechanical properties and stimulate porous implant osseointegration by promoting bone anabolism in type 1 diabetic rabbits[J]. Osteoporosis International, 2018, 29(5): 1177-1191. [67] Dean P M, Matthews E K, Sakamoto Y.Pancreatic islet cells: effects of monosaccharides, glycolytic intermediates and metabolic inhibitors on membrane potential and electrical activity[J]. The Journal of Physiology, 1975, 246(2): 459-478. [68] Lahbib A, Ghodbane S, Louchami K, et al.Effects of vitamin D on insulin secretion and glucose transporter GLUT2 under static magnetic field in rat[J]. Environmental Science & Pollution Research, 2015, 22(22): 18011-18016. [69] Elferchichi M, Mercier J, Ammari M, et al.Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle[J]. Environmental Science & Pollution Research, 2016, 23(2): 1265-1273. [70] Laszlo J F, Szilvasi J, Fenyi A, et al.Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice[J]. International Journal of Radiation Biology, 2011, 87(1): 36-45. [71] Hirose H, Nakahara T, Zhang Qiumei, et al.Static magnetic field with a strong magnetic field gradient (41.7T/m) induces c-Jun expression in HL-60 cells[J]. Vitro Cellular & Developmental Biology Animal, 2003, 39(8-9): 348-352. [72] Abdelmelek H, Molnar A, Servais S, et al.Skeletal muscle HSP72 and norepinephrine response to static magnetic field in rat[J]. Journal of Neural Trans- mission, 2006, 113(7): 821-827. [73] Mcleod B R, Liboff A R, Smith S D.Electromagnetic gating in ion channels[J]. Journal of Theoretical Biology, 1992, 158(1): 15-31. [74] Tenforde T S.Biological interactions of extremely- low-frequency electric and magnetic-fields[J]. Journal of Electroanalytical Chemistry and Interfacial Elec- trochemistry, 1991, 25(1): 1-17. [75] Iwasaka M, Ueno S.Magnetic-field parallel motion of living cells[J]. Journal of Applied Physics, 2005, 97(10): 377-380. [76] Ueno S, Iwasaka M, Kitajima T.Redistribution of dissolved-oxygen concentration under magnetic-fields up to 8-T[J]. Journal of Applied Physics, 1994, 75(10): 7174-7176. [77] Carter C S, Huang S C, Searby C C, et al.Exposure to static magnetic and electric fields treats type 2 diabetes[J]. Cell Metabolism, 2020, 32(4): 561-574.
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