电工技术学报  2017, Vol. 32 Issue (22): 264-274    DOI: 10.19595/j.cnki.1000-6753.tces.170146
高电压与绝缘技术 |
高频纳秒脉冲串作用下皮肤肿瘤热效应的多参数有限元仿真与实验
米彦1, 彭文成1, 芮少琴2, 况东东3, 罗庆3
1. 输配电装备及系统安全与新技术国家重点实验室(重庆大学) 重庆 400030。
2. 国家电网天津电力检修公司 天津 300010。
3. 重庆大学生物工程学院 重庆 400030
Thermal Effects in Skin Tumor Exposed to High-Frequency Nanosecond Pulse Bursts: Multi-Parametric Finite Element Simulation and Experiment
Mi Yan1, Peng Wencheng1, Rui Shaoqin2, Kuang Dongdong3, Luo Qing3
1. State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400030 China.
2. State Grid Tianjin Power Maintenance Company Tianjin 300010 China.
3. College of Bioengineering Chongqing University Chongqing 400030 China
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摘要 为综合传统微秒脉冲电场和纳秒脉冲电场治疗肿瘤的优点,提出一种高频纳秒脉冲串的脉冲形式来治疗肿瘤。研究此高频纳秒脉冲串在生物组织中产生的热效应,并通过多参数有限元方法对施加镊子电极的皮肤黑色素肿瘤的温度以及热损伤进行仿真。施加的电场强度范围为1~10kV/cm,脉宽范围为50~500ns,脉冲串内重复频率介于100kHz和1MHz之间,一串脉冲的长度为100μs,脉冲串重复频率为1Hz。对于皮肤肿瘤,施加电场强度5kV/cm、脉宽500ns、脉冲串内重复频率1MHz的脉冲,1s后肿瘤的最高温度仅为37.4℃,热损伤可以忽略不计。对不同电场强度、脉宽、重复频率下皮肤黑色素肿瘤的温度和热损伤进行仿真计算,研究肿瘤温度以及热损伤与脉冲参数的关系,并确定使肿瘤不发生热损伤的脉冲参数范围。对裸鼠在体黑色素肿瘤的温度进行实测,肿瘤的温升结果与仿真中的平均温度变化较为一致。
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米彦
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罗庆
关键词 高频纳秒脉冲串温度热损伤肿瘤有限元    
Abstract:Combined with the advantages of microsecond pulsed electric field and nanosecond pulsed electric field for the treatment of tumors, this work introduces high-frequency nanosecond pulse bursts. To study the thermal effects of the high-electric-field nanosecond pulses in tissue, a multi-parametric analysis is carried out based on a finite element model of skin with a melanoma tumor nipped by splint electrodes. The electric field ranges from 1 to 10kV/cm, the pulse width ranges from 50 to 500ns, and the frequency in the pulse bursts ranges between 100kHz and 1MHz. The total pulse length is 100μs, and the frequency of the pulse bursts is 1Hz. The simulated maximum temperature of the skin tumor is only 37.4℃ after 1s, and the thermal damage is negligible, where the pulse parameters are 5kV/cm, 500ns and 1MHz. The temperature and thermal damage of the melanoma tumor in the skin are simulated and calculated with different electric fields, different pulse widths and different frequencies. The relationship between the thermal effects on the tumor and the pulse parameters is researched, and pulse parameters for a tumor without thermal damage are ascertained. By measuring the temperature of melanoma tumors in nude mice in vivo, it shows that the change in experimental temperature of the tumors is consistent with the simulated average temperature.
Key wordsHigh-frequency    nanosecond    pulse    bursts,    temperature,    thermal    damage,    tumor,    finite    element    method   
收稿日期: 2017-02-15      出版日期: 2017-12-05
PACS: TM89  
基金资助:国家自然科学基金(51477022,51321063)和重庆市科委自然科学基金(cstc2014jcyjjq90001,cstc2016jcyjA0500)资助项目
通讯作者: 彭文成 男,1994年生,硕士研究生,研究方向为高电压新技术。E-mail: pengwencheng@cqu.edu.cn。   
作者简介: 米彦 男,1978年生,教授,博士生导师,研究方向为高电压新技术。E-mail: miyan@cqu.edu.cn
引用本文:   
米彦, 彭文成, 芮少琴, 况东东, 罗庆. 高频纳秒脉冲串作用下皮肤肿瘤热效应的多参数有限元仿真与实验[J]. 电工技术学报, 2017, 32(22): 264-274. Mi Yan, Peng Wencheng, Rui Shaoqin, Kuang Dongdong, Luo Qing. Thermal Effects in Skin Tumor Exposed to High-Frequency Nanosecond Pulse Bursts: Multi-Parametric Finite Element Simulation and Experiment. Transactions of China Electrotechnical Society, 2017, 32(22): 264-274.
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https://dgjsxb.ces-transaction.com/CN/10.19595/j.cnki.1000-6753.tces.170146          https://dgjsxb.ces-transaction.com/CN/Y2017/V32/I22/264