电工技术学报  2022, Vol. 37 Issue (17): 4269-4283    DOI: 10.19595/j.cnki.1000-6753.tces.210959
电工理论与新技术 |
基于矩阵式线圈的感应式磁声磁粒子浓度成像研究
闫孝姮, 李政兴, 孙迪, 陈伟华, 高鹏
辽宁工程技术大学电气与控制工程学院 葫芦岛 125000
Magnetoacoustic Concentration Tomography of Magnetic Nanoparticles with Magnetic Induction Based on Matrix Coil
Yan Xiaoheng, Li Zhengxing, Sun Di, Chen Weihua, Gao Peng
The Faculty of Electrical and Control Engineering Liaoning Technical University Huludao 125000 China
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摘要 感应式磁声磁粒子浓度成像(MACT-MI)是一种基于磁声耦合效应的磁性纳米粒子(MNPs)浓度成像新方法,为降低激励源幅值,产生更加稳定的声压信号,该文提出一种基于矩阵式线圈的磁声磁粒子浓度成像系统,采用天牛须-鱼群优化算法对矩阵式线圈进行优化设计,根据优化结果采用多物理场仿真软件COMSOL对MACT-MI的物理过程进行求解,并将结果与Maxwell线圈进行对比,同时基于实际生物组织环境中的MNPs分布,构建浓度渐变模型,得到了成像区域的磁力、声压分布。结果表明,该文设计的矩阵式线圈能在较小的激励下产生大小相等且分布更为均匀的梯度磁场,从而产生更为稳定的声压信号;根据所构建的浓度渐变模型,MNPs所受磁力和声压波形宽度均与渐变区域宽度成正比,声压峰值与渐变区域的浓度梯度成正比。研究结果可为成像装备的设计以及MACT-MI的后续实验乃至临床应用提供研究基础。
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闫孝姮
李政兴
孙迪
陈伟华
高鹏
关键词 磁声磁粒子浓度成像天牛须-鱼群算法矩阵式线圈浓度渐变磁力声压    
Abstract:Magnetoacoustic concentration tomography of magnetic nanoparticles (MNPs) with magnetic induction (MACT-MI) is a new method for MNPs concentration tomography. To reduce the amplitude of the excitation current source and produce a more stable magnetoacoustic signal, MACT-MI system based on matrix coils was studied. Optimal design of matrix coils used the artificial fish swarm algorithm based on beetle antennae search algorithm (BAS-AFSA). According to the optimization results the physical process of MACT-MI was solved by using COMSOL and then the results were compared with the results of Maxwell coils. A concentration gradient model was also constructed based on the distribution of MNPs in the actual biological tissue environment, and both the magnetic force and sound pressure distribution in the region of interest (ROI) were obtained. The results show that the matrix coils designed in this paper can produce a more stable sound pressure signal and a more uniformly distributed gradient magnetic field with equal size under a smaller excitation. According to the constructed concentration gradient model, both the magnetic force and the width of the sound pressure wave of MNPs are proportional to the width of the gradient region, and the peak value of sound pressure is proportional to the concentration gradient in the gradient region. The results provide a prospective basis for the design of imaging equipment, the follow-up experiments and clinical applications of MACT-MI.
Key wordsMagnetic nanoparticles with magnetic induction (MACT-MI)    artificial fish swarm algorithm based on beetle antennae search algorithm    matrix coils    concentration gradient    magnetic force    sound pressure   
收稿日期: 2021-06-30     
PACS: TM12  
引用本文:   
闫孝姮, 李政兴, 孙迪, 陈伟华, 高鹏. 基于矩阵式线圈的感应式磁声磁粒子浓度成像研究[J]. 电工技术学报, 2022, 37(17): 4269-4283. Yan Xiaoheng, Li Zhengxing, Sun Di, Chen Weihua, Gao Peng. Magnetoacoustic Concentration Tomography of Magnetic Nanoparticles with Magnetic Induction Based on Matrix Coil. Transactions of China Electrotechnical Society, 2022, 37(17): 4269-4283.
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