电工技术学报  2020, Vol. 35 Issue (22): 4621-4626    DOI: 10.19595/j.cnki.1000-6753.tces.191342
电工理论 |
电粒子成像方法及其正问题数值研究
刘婧1,2, 刘国强1,2
1.中国科学院电工研究所 北京 100190;
2.中国科学院大学 北京 100049
Electrical Particles Imaging Method and Numerical Study on the Forward Problem
Liu Jing1,2, Liu Guoqiang1,2
1. Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100190 China;
2. University of Chinese Academy of Sciences Beijing 100049 China
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摘要 纳米材料应用于临床医疗是现代医学发展的重要趋势。其中,靶向性的纳米材料在药物或基因的靶向运送等应用中前景广阔。对于磁导向性的磁性纳米颗粒,可采用磁粒子成像(MPI)技术进行体内成像,而另一类具有电导向性,该文中统称电性纳米颗粒的纳米材料,目前尚未有行之有效的体内无创成像方法。为解决这一难题,该文提出电粒子成像(EPI)方法,通过在注入电性纳米颗粒的生物体周围布置非接触电极阵列,提取电极阵列中检测电极电位与激励电极电位之间的相位差,根据电性纳米颗粒的极化性质,反演出电性纳米颗粒的浓度分布,实现生物组织内电性纳米颗粒的浓度成像。由于该方法尚处于初期探索阶段,需要首先进行可行性分析。该文借助于有限元仿真软件COMSOL,对电粒子成像方法的正问题进行建模求解。数值计算结果表明了该方法的可行性,为后期深入研究奠定理论基础。
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刘婧
刘国强
关键词 电粒子成像电性纳米颗粒正问题有限元法    
Abstract:The application of nanomaterials in clinical medicine is an important trend in modern medicine.Among them,targeted nanoparticles have broad prospects in targeting drugs or genes in vivo.So far,magnetic particles imaging (MPI) has been applied to image magnetic nanoparticles.However,the electric oriented nanoparticles,named electrical nanoparticles (ENPs) in this paper,have no effective in vivo imaging method.Therefore,this paper proposed a novel method called electrical particles imaging (EPI).In EPI,arrays of non-contact electrodes are arranged around organisms with injected electrical nanoparticles.The phase difference of the potential between the detecting electrode and the excitation electrode is extracted.According to the polarization properties of electrical nanoparticles,the concentration distribution of the electrical nanoparticles can be reconstructed through a corresponding inversion algorithm.Since the EPI method is still in the initial exploration stage,its feasibility needs to be demonstrated first.In this paper,the finite element simulation software COMSOL was employed to analyze the forward problem of the EPI method.Numerical results verified the proposed method,and laid a theoretical foundation for our future study.
Key wordsElectrica particles imaging (EPI)    electrical nanoparticles (ENPs)    forward problem    finite element method   
收稿日期: 2019-10-17     
PACS: TM93  
基金资助:国家自然科学基金(51907191)和北京市自然科学基金(3204057)资助项目
通讯作者: 刘国强,男,1971年生,研究员,博士生导师,研究方向为生物电磁检测与多物理场耦合成像。E-mail:gqliu@mail.iee.ac.cn   
作者简介: 刘婧,女,1990年生,博士,助理研究员,研究方向为电磁检测与成像。E-mail:liujing@mail.iee.ac.cn
引用本文:   
刘婧, 刘国强. 电粒子成像方法及其正问题数值研究[J]. 电工技术学报, 2020, 35(22): 4621-4626. Liu Jing, Liu Guoqiang. Electrical Particles Imaging Method and Numerical Study on the Forward Problem. Transactions of China Electrotechnical Society, 2020, 35(22): 4621-4626.
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