Abstract：In the clinical application of irreversible electroporation tumor therapy, because the ablation area generated by the electric field pulse is small, multi-electrode treatment need to achieve complete ablation of tumor tissue for patients with large tumor size. However, at present, multi-needle treatment is still predicted by the superposition of two treatment effects, which is not conducive to the development of an accurate treatment-planning. Aiming at this problem, based on the electric field distribution and ablation effect of irreversible electroporation tumor ablation with multi-electrode, a numerical model suitable for multi-electrode treatment is established. Based on analysis of the conductivity model, a dose-effect relationship model considering the cumulative effect under multi-needle treatment was established. The potato tissue ablation experiment was performed under the voltage of 500V, 600V, 700V, 800V and 1 000V, and compared the prediction results of the traditional model, the superposition model and the dose-response model. The results show that the accuracy and feasibility of the dose-response model (mean error is less than 5.04%), and it can be used for pre-treatment of multi-needle treatment guidance, providing theoretical and data support for the development of treatment options for clinical applications of irreversible electroporation.
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2020, Vol. 35 
