Effect of Different Patterns of Transcranial Magnetic Stimulation on the Correlation of Neural Network During Working Memory Task of Rats
Guo Miaomiao1,2, Wang Zhonghao1,2, Zhang Tianheng1,2, Ji Lihui1,2, Xu Guizhi1,2
1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology Tianjin 300130 China; 2. Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health Hebei University of Technology Tianjin 300130 China
Abstract：Transcranial magnetic stimulation (TMS) has been widely used in clinical neurologic regulation due to its painless and noninvasive characteristics. Working memory (WM) is an important cognitive function, but the effect mechanism of TMS on working memory function is still unclear and the influence of TMS with various modes on the nervous system is quite different. Therefore, it is of great clinical significance to explore the effect mechanism of TMS on working memory. In this paper, adult Wistar rats were divided into control group, repetitive transcranial magnetic stimulation (rTMS) group, continuous Theta burst stimulation (cTBS) group and intermittent Theta burst stimulation (iTBS) group. The local field potential signals (LFPs) of prefrontal cortex (PFC) in the four groups were collected synchronously by implanting multichannel electrodes in vivo during the T-maze working memory task. Finally, the effects of different modes of TMS on neural network in working memory were explored by comparative analysis of the behavioral differences, the correlation of LFPs and the network connection characteristics of LFPs in the four groups. The behavioral results showed that the time for the rats in the stimulation groups to reach the task correction criterion was less than that of the control group (P<0.05. The correlation results showed that the correlation coefficient of LFPs between electrode pairs in the stimulation model group was higher than that in the control group. The network connection density and the global efficiency of LFPs obviously increased in the stimulation group (P<0.05). In conclusion, iTBS, cTBS and rTMS can improve the association synchronization of PFC in adult Wistar rats to a certain extent, and the improvement effect of iTBS is the best, which can provide theoretical support for further exploring the effect of TMS on WM.
郭苗苗, 王中豪, 张天恒, 吉利辉, 徐桂芝. 经颅磁刺激模式差异性对大鼠工作记忆神经网络关联特性的影响研究[J]. 电工技术学报, 2021, 36(18): 3808-3820.
Guo Miaomiao, Wang Zhonghao, Zhang Tianheng, Ji Lihui, Xu Guizhi. Effect of Different Patterns of Transcranial Magnetic Stimulation on the Correlation of Neural Network During Working Memory Task of Rats. Transactions of China Electrotechnical Society, 2021, 36(18): 3808-3820.
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2021, Vol. 36 
