基于皮层-基底神经节环路模型的经颅磁声电刺激对大鼠行为决策影响的研究

doi:10.19595/j.cnki.1000-6753.tces.221807

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摘要

经颅磁声电刺激（Transcranial magneto-acousto-electrical stimulation, TMAES）是一种新型、无创、可改变不同脑区电活动的神经调控方法。前额叶皮层与基底神经节中各脑区相互影响,在行为决策中起着关键作用,然而目前涉及其调节机理的研究相对较少。前运动皮层神经元活性和前额叶皮层突触可塑性与行为决策关系密切。本文基于皮层-基底神经节回路模型,模拟分别对健康大鼠、帕金森大鼠施加刺激后,不同脑区在奖赏选择任务中的神经活动,仿真分析不同感应电流强度对皮层神经元放电率和脑区间突触权重的影响。并通过行为学实验进一步探讨经颅磁声电刺激对健康大鼠与帕金森模型大鼠行为决策的影响。仿真结果显示,对健康大鼠施加刺激可提高前额叶皮层与纹状体、前运动皮层之间的突触权重;对帕金森大鼠施加刺激可提高前运动皮层神经元放电率,调节前额叶皮层与纹状体、前运动皮层之间的突触权重。实验结果显示,施加刺激后,大鼠的学习探索能力和空间记忆能力均得到了提高,且帕金森模型大鼠受刺激的作用效果更显著。研究结果表明,经颅磁声电刺激可提高大鼠的运动积极性和学习效率,且有助于改善基底神经节的功能失衡。研究结果为进一步探索经颅磁声电刺激调节决策认知功能的作用机制奠定基础。

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关键词 ：经颅磁声电刺激, 皮层神经元, 基底神经节, 行为决策, 突触权重

Abstract：

Transcranial magneto-acousto-electrical stimulation (TMAES) is a novel noninvasive neuromodulation technique that can modulate electrical activity in different brain regions. Brain regions in the cortex and basal ganglia interact with each other and play a key role in behavioral selection and reinforcement learning. Based on the cortical-basal ganglia circuit model, this study explored the effect of TMAES on behavioral decision-making ability of rats, and further discussed the effect of stimulation on neural information transmission and spatial exploration ability of rats through animal experiments.
TMAES uses the coupling effect of magnetic field and ultrasound to generate induced current in nerve tissue, which in turn affects the neural activity of the cortex-basal ganglia circuit. The discharge rate of premotor cortex (PMC) neurons is related to exercise enthusiasm. The synaptic connection between prefrontal cortex (PFC) and striatum (STR) is involved in the evaluation of brain action value. The synaptic connection between PFC and PMC is closely related to learning and memory. The purpose of this paper is to investigate the regulatory mechanism of TMAES on the cortical-basal ganglia-cortical neural network in healthy and Parkinsonian states. Based on the cortical-basal ganglia-cortical circuit model, this paper simulated the neural activity of different brain regions in a reward selection task, and analyzed the effects of different induced current strengths on the firing rate of neurons and the synaptic weight between nuclei.
The simulation results showed that when TMAES was applied to healthy rats, the discharge rate of PMC nuclei corresponding to rewarding behavior increased, while the discharge rate of PMC nuclei corresponding to non-rewarding behavior decreased. When the induced current was 100 μA/cm², the number of rewarding behaviors in 1~200 trials increased from 177 to 195, and increased from 167 to 187 in 200~400 trials. At the same time, stimulation increased the synaptic weight, and was positively correlated with the induced current. The discharge rate of PMC nucleus and the prominent weight in Parkinson 's rats were significantly lower than those in healthy rats. After stimulation, the discharge rate corresponding to reward behavior increased, and the discharge rate corresponding to non-reward behavior decreased. Stimulation increased the prominent weight between PFC and STR corresponding to rewarding behavior in the direct pathway, and increased with the increase of induced current, but did not change the prominent weight between PFC and STR in the indirect pathway. In this study, the rat T maze experiment was further carried out, and the local field potential signal of rat PFC was obtained by in vivo multi-channel neural signal acquisition system. One-way ANOVA analysis of the number of days spent in the exploratory learning stage of rats showed that the spatial exploration ability of rats was improved after stimulation. Correlation analysis of 16-channel local field potential signals showed that TMAES could improve the correlation between rat channels and help promote information transmission between neural nuclei. The results showed that TMAES could improve the exercise enthusiasm and learning efficiency of rats, and help to improve the functional imbalance of basal ganglia in Parkinson 's rats.

Key words： Transcranial magneto-acousto-electrical stimulation cortical neurons basal ganglion decision-making synaptic weights

收稿日期: 2022-09-21

PACS:	TM12
	R318

基金资助:

国家自然科学基金（51877069）和河北省自然科学基金（E2021202184）资助项目

通讯作者: 张帅男,1978年生,博士生导师,主要从事生物电磁技术研究。E-mail：zs@hebut.edu.cn

作者简介: 由胜男女,1996年生,硕士研究生,主要从事生物电磁技术研究。E-mail：1601001467@qq.com

引用本文:

张帅, 由胜男, 党君武, 杜文静, 王磊. 基于皮层-基底神经节环路模型的经颅磁声电刺激对大鼠行为决策影响的研究[J]. 电工技术学报, 0, (): 230623-230623. Zhang Shuai, You Shengnan, Dang Junwu, Du Wenjing, Wang Lei. Effect of Transcranial Magneto-Acousto-Electrical Stimulation on Behavioral Decision-Making in Rats Based on a Cortical-Basal Ganglia Loop Model. Transactions of China Electrotechnical Society, 0, (): 230623-230623.

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