基于近似熵的磁刺激穴位脑功络构建与分析

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摘要针灸是基于传统中医的理论,经临床实践已证明其疗效,然而其作用机制仍不清楚。磁刺激穴位为研究针灸理论提供了一种新的方法。基于图论的复杂网络的构建和分析方法可以帮助研究脑功能网络的拓扑结构和理解大脑的工作机制。在该研究中,通过磁刺激内关穴（PC6）采集EEG信号;运用非线性动力学方法（近似熵）和复杂网络理论,基于磁刺激内关穴的脑电信号构建脑功能网络并对脑功能网络进行分析;对比分析了安静和磁刺激两种状态下的脑功能网络的拓扑性质。实验结果表明,基于刺激内关穴构建的脑功能网络,其拓扑结构发生了改变,网络连接增强,信息传输效率提高,并且“小世界”属性增强。

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	郭磊
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	于洪丽
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	李颖

关键词 ：脑电信号, 磁刺激, 内关穴, 脑功能网络, 近似熵

Abstract：Acupuncture is based on the theory of the traditional Chinese medicine. Its therapeutic effectiveness has been proved by clinical practice. However, its effect mechanism is still unclear. Magnetic stimulation at acupuncture point provides a new means for studying the theory of acupuncture. Based on the graph theory, the construction and analysis method of complex network can help to investigate the topology of brain functional network and understand the working mechanism of the brain. In this study, magnetic stimulation is used to stimulate neiguan(PC6) acupoint and EEG signal is recorded; using non-linear method(approximate entropy) and complex network theory, brain functional network based on EEG signal under magnetic stimulation at PC6 acupoint is constructed and analyzed; the features of complex network are comparatively analyzed between the quiescent and stimulated states. The experimental results show the topology of the network is changed, the connection of the network is enhanced, and the efficiency of information transmission is improved and the “small-world” property is stronger through stimulating PC6 acupoint.

Key words： EEG signal magnetic stimulation neiguan acupuncture point brain functional network approximate entropy

收稿日期: 2013-10-10 出版日期: 2015-06-29

PACS:

TM15

基金资助:中国高等教育博士点（20121317110002）,河北省自然科学基金（H2013202176）和河北省高等学校创新团队领军人才培育计划（LJRC003）资助项目

作者简介: 郭磊,男，1968年生，博士，教授，硕士生导师，研究方向为神经工程。王瑶,女，1988年生，博士研究生，研究方向为神经工程。

引用本文:

郭磊, 王瑶, 于洪丽, 尹宁, 李颖. 基于近似熵的磁刺激穴位脑功络构建与分析[J]. 电工技术学报, 2015, 30(10): 31-38. Guo Lei, Wang Yao, Yu Hongli, Yin Ning, Li Ying. Brain Functional Network Based on Approximate Entropy of EEG under Magnetic Stimulation at Acupuncture Point. Transactions of China Electrotechnical Society, 2015, 30(10): 31-38.

链接本文:

https://dgjsxb.ces-transaction.com/CN/Y2015/V30/I10/31

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