电工技术学报  2021, Vol. 36 Issue (4): 705-716    DOI: 10.19595/j.cnki.1000-6753.tces.201255
生物电工技术专题 |
功能磁共振成像在肿瘤学领域的应用
冯焕1,2, 姜晖1,2, 王雪梅1,2
1.生物电子学国家重点实验室(东南大学) 南京 210096;
2.东南大学生物科学与医学工程学院 南京 210096
Application of Functional Magnetic Resonance Imaging in the Field of Oncology
Feng Huan1,2, Jiang Hui1,2, Wang Xuemei1,2
1. State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China;
2. School of Biological Science & Medical Engineering Southeast University Nanjing 210096 China
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摘要 功能磁共振成像(fMRI)作为一种非侵入性和非电离辐射成像,可对全身各系统疾病进行成像诊断,如心血管疾病、神经退行性疾病、肿瘤、创伤和炎症等。肿瘤是全球第二大死亡原因,各国科学家都致力于攻克肿瘤。通过fMRI对肿瘤进行成像,可实现肿瘤的分型、分级和分期,对制定治疗方案、评估疗效及预后等有重大作用。该文总结和探讨六种fMRI,包括弥散加权成像(DWI)、弥散张量成像(DTI)、灌注加权成像(PWI)、磁敏感加权成像(SWI)、磁共振波谱成像(MRS)和血氧水平依赖的功能磁共振成像(BOLD-fMRI),以及多模态正电子发射断层扫描/磁共振成像(PET/MRI)在肿瘤学领域的应用,并对其在相关治疗领域的应用前景进行 展望。
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关键词 功能磁共振成像多模态成像肿瘤正电子发射断层成像/磁共振成像    
Abstract:As a non-invasive and non-ionizing radiation imaging, functional magnetic resonance imaging (fMRI) can be used for imaging diagnosis of systemic diseases, such as cardiovascular diseases, neurodegenerative diseases, tumors, trauma, inflammation and so on. Tumor is the second leading cause of death in the world, and scientists from all over the world are committed to tackling tumors. fMRI imaging of tumors can achieve the classification, grading and staging of tumors, which plays an important role in the formulation of treatment plans, evaluation and prediction of curative effect. This paper summarizes and discusses 6 types of fMRI, including diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), perfusion weighted imaging (PWI), susceptibility weighted imaging (SWI), magnetic resonance spectroscopy (MRS), and blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI). The application research of multimodal imaging positron emission tomography/magnetic resonance imaging (PET/MRI) in the field of oncology and the application prospects in related therapeutic fields are discussed.
Key wordsFunctional magnetic resonance imaging    multimodal imaging    cancer    positron emission tomography/magnetic resonance imaging (PET/MRI)   
收稿日期: 2020-09-21     
PACS: R445.2  
基金资助:江苏省重点研发计划(BE2019716)和国家自然科学基金(91753106)资助项目
通讯作者: 王雪梅 女,1968年生,教授,博士生导师,研究方向为生物电子与生物传感、多模态生物成像、纳米医学和精准医疗。E-mail: xuewang@seu.edu.cn   
作者简介: 冯 焕 女,1995年生,硕士研究生,研究方向为生物传感和多模态成像。E-mail: 220181844@seu.edu.cn
引用本文:   
冯焕, 姜晖, 王雪梅. 功能磁共振成像在肿瘤学领域的应用[J]. 电工技术学报, 2021, 36(4): 705-716. Feng Huan, Jiang Hui, Wang Xuemei. Application of Functional Magnetic Resonance Imaging in the Field of Oncology. Transactions of China Electrotechnical Society, 2021, 36(4): 705-716.
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https://dgjsxb.ces-transaction.com/CN/10.19595/j.cnki.1000-6753.tces.201255          https://dgjsxb.ces-transaction.com/CN/Y2021/V36/I4/705