Abstract：Recently, pulsed electric fields (PEFs) has shown broad prospects in non-thermal minimally invasive treatment of tumors with its unique biomedical and therapeutic effect. Using practical and precise numerical model to effectively estimate the tissue electroporation effect is a regular and key technology to further promote the application of PEFs. This paper proposed a method, which based on low-voltage measurement pulses, to get insight into the dynamic process of tissue ablation by PEFs. Then a dynamic conductivity numerical model, which considered the time, electric field cumulative effects and thermal field cumulative effects was established to simulate the changes tissue electrical characteristics in real-time. The error between the calculated data and the experimental data was less than 5% over a broad range of applied pulse strength, which shows a good feasibility and accuracy. This numerical model could be used to predict dynamic changes in tissue conductivity and the space-time distribution of eletro-thermal coupling field under PEFs with different parameters, which provides method reference and data support for further improvement of treatment planning.
刘红梅, 姚陈果, 董守龙, 赵亚军, 马剑豪. 基于测量信号的不可逆电穿孔动态过程数值模拟及分析[J]. 电工技术学报, 2019, 34(18): 3732-3740.
Liu Hongmei, Yao Chenguo, Dong Shoulong, Zhao Yajun, Ma Jianhao. Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal. Transactions of China Electrotechnical Society, 2019, 34(18): 3732-3740.
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2019, Vol. 34 
