Simulation Analysis on Dynamic Process of Electroporation by the Model Based on Energy Probability and Pore Force in Cell Exposed to Pulsed Electric Field
Yao Chenguo, Lv Yanpeng, Zhao Yajun ,Dong Shoulong, Liu Hongmei
State Key Laboratory of Power Transmission Equipment System Security and New TechnologyChongqing University Chongqing 400030 China
Abstract:Matlab is used to for numerical analysis on the transmembrane voltage,the radius of the micro-pores,pore force,generation and evolution of pores in a spherical cell exposed to 1 kV/cm、100 μs pulsed electric field (PEF).This model differs traditional model in two distinct ways.At first,this study uses the energy probability model to decide the initial time of pore expansion.When the probability that the injected energy exceeds the minimum energy of pore is greater than 0.99,the pore can expand.Secondly,pore force model is used to describe the development and distribution of pore in the cell membrane,and a new parameter-pore momentum is put forward to decide the size of the pores.Results show that electroporation happens on most distributions except the poles regions.Pore force is closed to zero at most regions which mean the balance occurs on these regions.However,pore force near poles regions is still positive,so pores are expanding if the time of the pulse is extended.This model can be a useful tool to decide pore formation and prediction of pore development.
姚陈果 ,吕彦鹏 ,赵亚军 ,董守龙,刘红梅. 基于能量概率与微孔力模型的脉冲电场对细胞电穿孔动态过程的仿真分析[J]. 电工技术学报, 2016, 31(23): 141-149.
Yao Chenguo, Lv Yanpeng, Zhao Yajun ,Dong Shoulong, Liu Hongmei. Simulation Analysis on Dynamic Process of Electroporation by the Model Based on Energy Probability and Pore Force in Cell Exposed to Pulsed Electric Field. Transactions of China Electrotechnical Society, 2016, 31(23): 141-149.
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