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| Effects of High-Frequency Immediate Magnetic Stimulation on Neuronal Excitability and Voltage-Gated Na+ and K+ Channels |
| Zhu Haijun1,2, Yin Xiaonan1,2, Ding Chong1,2, Hou Wentao1,2, Xu Guizhi1,2 |
1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology Tianjin 300130 China;
2. Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health Hebei University of Technology Tianjin 300130 China |
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Abstract As a non-invasive brain stimulation technique, transcranial magnetic stimulation bas been widely used in scientific research and clinical applications due to its good effect in neuromodulation. This paper aims to study the effects of different intensities of immediate magnetic stimulation (MS) on neuronal excitability, voltage-gated sodium channels (VGSCs) and voltage-gated potassium channels (Kv) . High frequency immediate MS of 0T, 0.3T and 0.5T was applied to acute mouse brain slices. Whole-cell patch-clamp technique was used to record the resting membrane potential and evoked nerve discharge of hippocampal dentate gyrus granule neurons, as well as the channel currents of voltage-gated sodium channel, transient outward potassium channel and delayed rectifier potassium channel during activation, inactivation, and recovery processes. The results show that MS can change the dynamic characteristics of VGSCs and Kv channels to active sodium currents and inhibit potassium currents, thereby increasing neuronal excitability. Moreover, this neuroregulatory effect of MS is intensity-dependent.
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Received: 18 September 2020
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2021, Vol. 36 
