电粒子成像方法及其正问题数值研究

doi:10.19595/j.cnki.1000-6753.tces.191342

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Abstract The application of nanomaterials in clinical medicine is an important trend in modern medicine.Among them,targeted nanoparticles have broad prospects in targeting drugs or genes in vivo.So far,magnetic particles imaging (MPI) has been applied to image magnetic nanoparticles.However,the electric oriented nanoparticles,named electrical nanoparticles (ENPs) in this paper,have no effective in vivo imaging method.Therefore,this paper proposed a novel method called electrical particles imaging (EPI).In EPI,arrays of non-contact electrodes are arranged around organisms with injected electrical nanoparticles.The phase difference of the potential between the detecting electrode and the excitation electrode is extracted.According to the polarization properties of electrical nanoparticles,the concentration distribution of the electrical nanoparticles can be reconstructed through a corresponding inversion algorithm.Since the EPI method is still in the initial exploration stage,its feasibility needs to be demonstrated first.In this paper,the finite element simulation software COMSOL was employed to analyze the forward problem of the EPI method.Numerical results verified the proposed method,and laid a theoretical foundation for our future study.

Key words： Electrica particles imaging (EPI) electrical nanoparticles (ENPs) forward problem finite element method

Received: 17 October 2019

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TM93

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	Liu Jing
	Liu Guoqiang

Cite this article:

Liu Jing,Liu Guoqiang. Electrical Particles Imaging Method and Numerical Study on the Forward Problem[J]. Transactions of China Electrotechnical Society, 2020, 35(22): 4621-4626.

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https://dgjsxb.ces-transaction.com/EN/10.19595/j.cnki.1000-6753.tces.191342 OR https://dgjsxb.ces-transaction.com/EN/Y2020/V35/I22/4621

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