基于太赫兹时域光谱技术的皮肤水分含量评估

doi:10.19595/j.cnki.1000-6753.tces.191737

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摘要太赫兹波以其独特的水分敏感性在生物组织的水分检测中展现出广阔的应用前景,太赫兹时域光谱（THz-TDs）技术与有效介质理论结合可以对皮肤组织的水分含量进行评估,但是对皮肤水分含量的变化进行准确定量感知仍然是尚未解决的问题,需要稳定的评估方法并分析其评估的准确性和影响因素。该文首先根据人体皮肤组织的结构和水分分布规律,定义三种皮肤水分含量梯度分布曲线,提出以反射率为优化目标的皮肤水分定量评估方法。然后采用遗传算法和列文伯格-马夸尔特（LM）相结合的混合算法对目标函数进行优化求解,使用反射式太赫兹测量系统对小手臂皮肤进行阻塞测量实验,得到时域信号和反射率的变化规律。最后讨论不同水分含量初始规律和不同有效介质模型对皮肤水分含量评估准确性的影响。结果表明,角质层水分分布规律和有效介质模型的选取对水分含量的绝对评估结果影响均很大,有效介质模型对水分含量的变化量影响较小,选择确定的水分分布规律和有效介质模型可以准确地评估皮肤水分含量的变化。该文研究可为太赫兹皮肤烧伤和皮肤疾病检测提供理论支撑。

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关键词 ：太赫兹时域光谱, 皮肤水分含量, 有效介质模型, 反射率, 混合算法

Abstract：Terahertz wave has shown a broad application prospect in the detection of moisture in biological tissues due to its unique moisture sensitivity. The combination of terahertz time domain spectroscopy (THz-TDs) and effective medium theory can be applied to evaluate the moisture content of skin, but its accurate and quantitative perception of changes in skin moisture content is still an unresolved problem. Therefore, a stable assessment method and the evaluation of its accuracy and influencing factors are needed. This paper defined three skin moisture content gradient distribution curves according to the structure of human skin tissue, and proposed a quantitative evaluation method of skin moisture content with reflectance as the optimization target, and then used a hybrid algorithm combining genetic and LM algorithm to solve the objective function. Using the reflection terahertz measurement system, an occluded forearm skin measurement experiment was carried out, and the variation law of the time-domain signal and reflectance was obtained. Finally, the influence of different initial water distribution laws and different effective medium models on the accuracy of skin moisture content assessment was discussed. The results show that the initial moisture distribution law and the selection of effective medium model both have a great influence on the evaluation results of the absolute moisture content, and the effective medium models have little difference on the moisture content change. Choosing a certain water distribution law and effective medium model can accurately evaluate the change of skin moisture content. This paper can provide theoretical support for terahertz detection of skin burns and skin diseases.

Key words： Terahertz time domain spectroscopy water concentration of skin effective medium model reflectivity hybrid algorithm

收稿日期: 2020-03-20

PACS:

TM15

基金资助:国家自然科学基金面上项目（51777023）和国网浙江省电力有限公司科技项目（5211DS18002W）资助

通讯作者: 杨帆男,1980年生,教授,博士生导师,研究方向为电磁场数值计算及其应用。E-mail: yangfancqu@cqu.edu.cn

作者简介: 余晓男,1993年生,博士研究生,研究方向为太赫兹光谱及其成像技术。E-mail: yuxiao@cqu.edu.cn

引用本文:

杨帆, 余晓, 刘黎, 王少华, 韩升. 基于太赫兹时域光谱技术的皮肤水分含量评估[J]. 电工技术学报, 2021, 36(4): 777-786. Yang Fan, Yu Xiao, Liu Li, Wang Shaohua, Han Sheng. Water Content Evaluation of Skin Tissue Based on Terahertz Time Domain Spectroscopy. Transactions of China Electrotechnical Society, 2021, 36(4): 777-786.

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