The Finite Difference Time Domain Simulation of the Distribution of Irreversible Electroporation Ablation Area in Liver Tissue by Nanosecond Electrical Pulse
Hu Yanan, Bao Jiali, Zhu Jinjun, Zhu Chaoyang, Cen Zenan
Research Team of Biophysics and Medical Engineering Zhejiang Provincial Key Laboratory of Bioelectromagnetics School of Medicine Zhejiang University Hangzhou 310058 China
Abstract：Nanosecond pulse electrical fields (nsPEFs) are a new type of electrosurgical technology, which can be used to remove the tumor without damaging the surrounding tissues, especially the blood vessels and the organs. Determining the nsPEFs parameters, such as voltage, duration, number and rate, etc., is the key to the design of preoperative treatment plan. Taken a human model Duke as the object, the electric field distribution, energy density and ablation area with the electric pulse waveform, pulse voltage and electrode spacing in liver tissue were simulated by the finite difference time domain (FDTD) in the human bioelectromagnetic simulation software platform Sim4Life. The results showed that the electric field intensity in the center of the electrodes was higher than that in the periphery of the electrodes, and the pulse wave pattern did not significantly change the peak electric field and energy density distribution in liver tissue. The ablation area wrapped the electrodes. The pulse pattern did not change the ablation area, but the pulse voltage and electrode spacing had great influence on the ablation area. Therefore, the FDTD can be used for preoperative design of electrical pulse treatment plan, the pulse voltage and electrode spacing are the main design parameters, and Sim4Life is a good platform for treatment plan design.
胡亚楠, 包家立, 朱金俊, 朱朝阳, 岑泽南. 纳秒电脉冲对肝脏组织不可逆电穿孔消融区分布的时域有限差分法仿真[J]. 电工技术学报, 2021, 36(18): 3841-3850.
Hu Yanan, Bao Jiali, Zhu Jinjun, Zhu Chaoyang, Cen Zenan. The Finite Difference Time Domain Simulation of the Distribution of Irreversible Electroporation Ablation Area in Liver Tissue by Nanosecond Electrical Pulse. Transactions of China Electrotechnical Society, 2021, 36(18): 3841-3850.
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2021, Vol. 36 
