Abstract：In order to research the biomedical mechanism of pulsed electric field (PEF), the equivalent dielectric-circuit compound model of spherical biological cell and the method for calculating the transfer functions of inner and outer membranes are presented in this paper. The time-domain solution of transmembrane potential induced by time-varying electric field is introduced, and the relationship between electric field parameters and transmembrane potential is also analyzed. It is found that different duration can result in different selective effect on inner and outer membranes. Frequency-domain analysis shows that inner and outer membranes exposed to PEF exhibit band-pass and low-pass filter characteristic, respectively. Therefore, different biomedical effects will be induced in response to different field. Both academic analyses and medical experiment results show that the dielectric-circuit compound model agrees well with the dielectric model and the circuit model, and can give explanation for the electroporation and apoptosis induction. The dielectric-circuit compound model provides theoretical guidance for parameter selection and mechanism study on application of PEF in tumor treatment.
米彦, 姚陈果, 李成祥, 廖瑞金, 孙才新. 基于场-路复合模型的细胞内外膜跨膜电位时频特性[J]. 电工技术学报, 2011, 26(2): 14-20.
Mi Yan, Yao Chenguo, Li Chengxiang, Liao Ruijin, Sun Caixin. Time-Frequency Characteristics of Transmenbrane Potentials on Cellular Inner and Outer Membranes Based on Dielectric-Circuit Compound Model. Transactions of China Electrotechnical Society, 2011, 26(2): 14-20.
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2011, Vol. 26 
