纳秒电脉冲对肝脏组织不可逆电穿孔消融区分布的时域有限差分法仿真

doi:10.19595/j.cnki.1000-6753.tces.L90288

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Abstract Nanosecond pulse electrical fields (nsPEFs) are a new type of electrosurgical technology, which can be used to remove the tumor without damaging the surrounding tissues, especially the blood vessels and the organs. Determining the nsPEFs parameters, such as voltage, duration, number and rate, etc., is the key to the design of preoperative treatment plan. Taken a human model Duke as the object, the electric field distribution, energy density and ablation area with the electric pulse waveform, pulse voltage and electrode spacing in liver tissue were simulated by the finite difference time domain (FDTD) in the human bioelectromagnetic simulation software platform Sim4Life. The results showed that the electric field intensity in the center of the electrodes was higher than that in the periphery of the electrodes, and the pulse wave pattern did not significantly change the peak electric field and energy density distribution in liver tissue. The ablation area wrapped the electrodes. The pulse pattern did not change the ablation area, but the pulse voltage and electrode spacing had great influence on the ablation area. Therefore, the FDTD can be used for preoperative design of electrical pulse treatment plan, the pulse voltage and electrode spacing are the main design parameters, and Sim4Life is a good platform for treatment plan design.

Key words： Electroporation irreversible electroporation nanoknife simulation finite difference time domain (FDTD)

Received: 08 July 2020

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TM836

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	Hu Yanan
	Bao Jiali
	Zhu Jinjun
	Zhu Chaoyang
	Cen Zenan

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Hu Yanan,Bao Jiali,Zhu Jinjun等. The Finite Difference Time Domain Simulation of the Distribution of Irreversible Electroporation Ablation Area in Liver Tissue by Nanosecond Electrical Pulse[J]. Transactions of China Electrotechnical Society, 2021, 36(18): 3841-3850.

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https://dgjsxb.ces-transaction.com/EN/10.19595/j.cnki.1000-6753.tces.L90288 OR https://dgjsxb.ces-transaction.com/EN/Y2021/V36/I18/3841

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