基于测量信号的不可逆电穿孔动态过程数值模拟及分析

doi:10.19595/j.cnki.1000-6753.tces.181157

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Abstract Recently, pulsed electric fields (PEFs) has shown broad prospects in non-thermal minimally invasive treatment of tumors with its unique biomedical and therapeutic effect. Using practical and precise numerical model to effectively estimate the tissue electroporation effect is a regular and key technology to further promote the application of PEFs. This paper proposed a method, which based on low-voltage measurement pulses, to get insight into the dynamic process of tissue ablation by PEFs. Then a dynamic conductivity numerical model, which considered the time, electric field cumulative effects and thermal field cumulative effects was established to simulate the changes tissue electrical characteristics in real-time. The error between the calculated data and the experimental data was less than 5% over a broad range of applied pulse strength, which shows a good feasibility and accuracy. This numerical model could be used to predict dynamic changes in tissue conductivity and the space-time distribution of eletro-thermal coupling field under PEFs with different parameters, which provides method reference and data support for further improvement of treatment planning.

Key words： Electroporation dynamic conductivity numerical modelling irreversible electro- poration treatment plan biological effect feedback signal

Received: 06 July 2018 Published: 26 September 2019

PACS:	TM11
	TM836
	Q64

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	Articles by authors
	Liu Hongmei
	Yao Chenguo
	Dong Shoulong
	Zhao Yajun
	Ma Jianhao

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Liu Hongmei,Yao Chenguo,Dong Shoulong等. Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal[J]. Transactions of China Electrotechnical Society, 2019, 34(18): 3732-3740.

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https://dgjsxb.ces-transaction.com/EN/10.19595/j.cnki.1000-6753.tces.181157 OR https://dgjsxb.ces-transaction.com/EN/Y2019/V34/I18/3732

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