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Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal |
Liu Hongmei, Yao Chenguo, Dong Shoulong, Zhao Yajun, Ma Jianhao |
State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400030 China |
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Abstract Recently, pulsed electric fields (PEFs) has shown broad prospects in non-thermal minimally invasive treatment of tumors with its unique biomedical and therapeutic effect. Using practical and precise numerical model to effectively estimate the tissue electroporation effect is a regular and key technology to further promote the application of PEFs. This paper proposed a method, which based on low-voltage measurement pulses, to get insight into the dynamic process of tissue ablation by PEFs. Then a dynamic conductivity numerical model, which considered the time, electric field cumulative effects and thermal field cumulative effects was established to simulate the changes tissue electrical characteristics in real-time. The error between the calculated data and the experimental data was less than 5% over a broad range of applied pulse strength, which shows a good feasibility and accuracy. This numerical model could be used to predict dynamic changes in tissue conductivity and the space-time distribution of eletro-thermal coupling field under PEFs with different parameters, which provides method reference and data support for further improvement of treatment planning.
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Received: 06 July 2018
Published: 26 September 2019
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