Transactions of China Electrotechnical Society  2019, Vol. 34 Issue (18): 3732-3740    DOI: 10.19595/j.cnki.1000-6753.tces.181157
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Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal
Liu Hongmei, Yao Chenguo, Dong Shoulong, Zhao Yajun, Ma Jianhao
State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400030 China

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Abstract  Recently, pulsed electric fields (PEFs) has shown broad prospects in non-thermal minimally invasive treatment of tumors with its unique biomedical and therapeutic effect. Using practical and precise numerical model to effectively estimate the tissue electroporation effect is a regular and key technology to further promote the application of PEFs. This paper proposed a method, which based on low-voltage measurement pulses, to get insight into the dynamic process of tissue ablation by PEFs. Then a dynamic conductivity numerical model, which considered the time, electric field cumulative effects and thermal field cumulative effects was established to simulate the changes tissue electrical characteristics in real-time. The error between the calculated data and the experimental data was less than 5% over a broad range of applied pulse strength, which shows a good feasibility and accuracy. This numerical model could be used to predict dynamic changes in tissue conductivity and the space-time distribution of eletro-thermal coupling field under PEFs with different parameters, which provides method reference and data support for further improvement of treatment planning.
Key wordsElectroporation      dynamic conductivity      numerical modelling      irreversible electro- poration      treatment plan      biological effect      feedback signal     
Received: 06 July 2018      Published: 26 September 2019
PACS: TM11  
  TM836  
  Q64  
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Liu Hongmei
Yao Chenguo
Dong Shoulong
Zhao Yajun
Ma Jianhao
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Liu Hongmei,Yao Chenguo,Dong Shoulong等. Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal[J]. Transactions of China Electrotechnical Society, 2019, 34(18): 3732-3740.
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