包含频率色散效应的细胞膜和核膜跨膜电位的仿真

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Abstract Based on double-shell dielectric model of spherical unicellular cell, full-circuit equivalent model of spherical unicellular cell is proposed with the consideration of frequency- dispersion by using Debye model. Then amplitude-frequency characteristics of trans-membrane potentials of plasma membrane and nuclear membrane with frequency-dispersion are calculated, and the results indicate that trans-membrane of plasma membrane and nuclear membrane can be greatly changed when the frequency of applied pulsed electric fields(PEF) exceeds 10⁸Hz, specifically, trans-membrane potential will gain another 5dB within the spectral of [10⁸Hz, 10¹¹Hz]. Two typical parameters of PEF are selected to investigate the time domain response of trans-membrane of plasma membrane and nuclear membrane, and the results demonstrate that bioelectric effects of cell can be more accurately forecasted with the consideration of frequency-dispersion.

Key words： Double-shell dielectric model Debye model frequency dispersion trans-membrane potential pulsed electric fields (PEF).

Received: 01 July 2013 Published: 26 March 2014

PACS:	TM836
	Q64

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	Guo Fei
	Yao Chenguo
	Li Chengxiang
	Mi Yan

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Guo Fei,Yao Chenguo,Li Chengxiang等. Simulation Study of Trans-Membrane Potential of Plasma and Nuclear Membranes with Frequency-Dispersion[J]. Transactions of China Electrotechnical Society, 2013, 28(11): 182-188.

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http://dgjsxb.ces-transaction.com/EN/ OR http://dgjsxb.ces-transaction.com/EN/Y2013/V28/I11/182

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