Abstract To explore the influence of the mechanical properties of cell membrane on electroporation, cell membrane was regarded as a hyperelastic material, and an electromechanical coupling model of local single pore on the cell membrane was established in COMSOL. The influence of the elastic strain energy of the cell membrane on the pore formation was analyzed and the difference of pore formation with different elastic modulus of the cell membrane was compared. The results show that the strain energy of the cell membrane increases the energy barrier for transition from hydrophobic pore to hydrophilic pore. The greater the elastic modulus of the cell membrane, the greater the energy barrier is, and the two are linearly related. On the other hand, the increased strain energy stabilizes the pores and prevents them from expanding indefinitely, and the stable size is related to the mechanical properties of the cell membrane and the transmembrane potential. This paper reveals the importance role of the mechanical properties of the cell membrane in electroporation through simulation, which provides a theoretical reference for studying the influence mechanism of cell structure on electroporation.
Mi Yan,Wu Xiao,Xu Jin等. Simulation Study on the Effect of Cell Membrane Mechanical Properties on Electroporation[J]. Transactions of China Electrotechnical Society, 2022, 37(17): 4326-4334.
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