基于能量概率与微孔力模型的脉冲电场对细胞电穿孔动态过程的仿真分析

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Abstract Matlab is used to for numerical analysis on the transmembrane voltage,the radius of the micro-pores,pore force,generation and evolution of pores in a spherical cell exposed to 1 kV/cm、100 μs pulsed electric field (PEF).This model differs traditional model in two distinct ways.At first,this study uses the energy probability model to decide the initial time of pore expansion.When the probability that the injected energy exceeds the minimum energy of pore is greater than 0.99,the pore can expand.Secondly,pore force model is used to describe the development and distribution of pore in the cell membrane,and a new parameter-pore momentum is put forward to decide the size of the pores.Results show that electroporation happens on most distributions except the poles regions.Pore force is closed to zero at most regions which mean the balance occurs on these regions.However,pore force near poles regions is still positive,so pores are expanding if the time of the pulse is extended.This model can be a useful tool to decide pore formation and prediction of pore development.

Key words： Electroporation transmembrane voltage energy probability pore force

Received: 05 July 2015 Published: 26 December 2016

PACS:	TM151
	TM836
	Q64

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	Articles by authors
	Yao Chenguo
	Lv Yanpeng
	Zhao Yajun
	Dong Shoulong
	Liu Hongmei

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Yao Chenguo,Lv Yanpeng,Zhao Yajun等. Simulation Analysis on Dynamic Process of Electroporation by the Model Based on Energy Probability and Pore Force in Cell Exposed to Pulsed Electric Field[J]. Transactions of China Electrotechnical Society, 2016, 31(23): 141-149.

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https://dgjsxb.ces-transaction.com/EN/ OR https://dgjsxb.ces-transaction.com/EN/Y2016/V31/I23/141

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