基于皮层-基底神经节环路模型的经颅磁声电刺激对大鼠行为决策影响的研究

doi:10.19595/j.cnki.1000-6753.tces.221807

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Abstract

Transcranial magneto-acousto-electrical stimulation (TMAES) is a novel noninvasive neuromodulation technique that can modulate electrical activity in different brain regions. Brain regions in the cortex and basal ganglia interact with each other and play a key role in behavioral selection and reinforcement learning. Based on the cortical-basal ganglia circuit model, this study explored the effect of TMAES on behavioral decision-making ability of rats, and further discussed the effect of stimulation on neural information transmission and spatial exploration ability of rats through animal experiments.
TMAES uses the coupling effect of magnetic field and ultrasound to generate induced current in nerve tissue, which in turn affects the neural activity of the cortex-basal ganglia circuit. The discharge rate of premotor cortex (PMC) neurons is related to exercise enthusiasm. The synaptic connection between prefrontal cortex (PFC) and striatum (STR) is involved in the evaluation of brain action value. The synaptic connection between PFC and PMC is closely related to learning and memory. The purpose of this paper is to investigate the regulatory mechanism of TMAES on the cortical-basal ganglia-cortical neural network in healthy and Parkinsonian states. Based on the cortical-basal ganglia-cortical circuit model, this paper simulated the neural activity of different brain regions in a reward selection task, and analyzed the effects of different induced current strengths on the firing rate of neurons and the synaptic weight between nuclei.
The simulation results showed that when TMAES was applied to healthy rats, the discharge rate of PMC nuclei corresponding to rewarding behavior increased, while the discharge rate of PMC nuclei corresponding to non-rewarding behavior decreased. When the induced current was 100 μA/cm², the number of rewarding behaviors in 1~200 trials increased from 177 to 195, and increased from 167 to 187 in 200~400 trials. At the same time, stimulation increased the synaptic weight, and was positively correlated with the induced current. The discharge rate of PMC nucleus and the prominent weight in Parkinson 's rats were significantly lower than those in healthy rats. After stimulation, the discharge rate corresponding to reward behavior increased, and the discharge rate corresponding to non-reward behavior decreased. Stimulation increased the prominent weight between PFC and STR corresponding to rewarding behavior in the direct pathway, and increased with the increase of induced current, but did not change the prominent weight between PFC and STR in the indirect pathway. In this study, the rat T maze experiment was further carried out, and the local field potential signal of rat PFC was obtained by in vivo multi-channel neural signal acquisition system. One-way ANOVA analysis of the number of days spent in the exploratory learning stage of rats showed that the spatial exploration ability of rats was improved after stimulation. Correlation analysis of 16-channel local field potential signals showed that TMAES could improve the correlation between rat channels and help promote information transmission between neural nuclei. The results showed that TMAES could improve the exercise enthusiasm and learning efficiency of rats, and help to improve the functional imbalance of basal ganglia in Parkinson 's rats.

Key words： Transcranial magneto-acousto-electrical stimulation cortical neurons basal ganglion decision-making synaptic weights

Received: 21 September 2022

PACS:	TM12
	R318

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	Zhang Shuai
	You Shengnan
	Dang Junwu
	Du Wenjing
	Wang Lei

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Zhang Shuai,You Shengnan,Dang Junwu等. Effect of Transcranial Magneto-Acousto-Electrical Stimulation on Behavioral Decision-Making in Rats Based on a Cortical-Basal Ganglia Loop Model[J]. Transactions of China Electrotechnical Society, 0, (): 230623-230623.

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https://dgjsxb.ces-transaction.com/EN/10.19595/j.cnki.1000-6753.tces.221807 OR https://dgjsxb.ces-transaction.com/EN/Y0/V/I/230623

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