Abstract In the clinical application of irreversible electroporation tumor therapy, because the ablation area generated by the electric field pulse is small, multi-electrode treatment need to achieve complete ablation of tumor tissue for patients with large tumor size. However, at present, multi-needle treatment is still predicted by the superposition of two treatment effects, which is not conducive to the development of an accurate treatment-planning. Aiming at this problem, based on the electric field distribution and ablation effect of irreversible electroporation tumor ablation with multi-electrode, a numerical model suitable for multi-electrode treatment is established. Based on analysis of the conductivity model, a dose-effect relationship model considering the cumulative effect under multi-needle treatment was established. The potato tissue ablation experiment was performed under the voltage of 500V, 600V, 700V, 800V and 1 000V, and compared the prediction results of the traditional model, the superposition model and the dose-response model. The results show that the accuracy and feasibility of the dose-response model (mean error is less than 5.04%), and it can be used for pre-treatment of multi-needle treatment guidance, providing theoretical and data support for the development of treatment options for clinical applications of irreversible electroporation.
Yao Chenguo,Zheng Shuang,Liu Hongmei等. Model of Irreversible Electroporation Dose-Effect Relationship for Clinical Multi-Needle Ablation Tumors[J]. Transactions of China Electrotechnical Society, 2020, 35(11): 2491-2498.
[1] Weaver J C.Electroporation of cells and tissues[J]. IEEE Transactions on Plasma Science, 2000, 28(1): 24-33. [2] Lü Yanpeng, Yao Chenguo, Rubinsky B.A conceivable mechanism responsible for the synergy of high and low voltage irreversible electroporation pulses[J]. Annals of Biomedical Engineering, 2019, 47(7): 1552-1563. [3] Domenge C, Orlowski S, Luboinski B, et al.Antitumor electrochemotherapy: new advances in the clinical protocol[J]. Cancer, 2015, 77(5): 956-963. [4] Heller R, Jaroszeski M J, Reintgen D S, et al.Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin[J]. Cancer, 2015, 83(1): 148-157. [5] 米彦, 徐进, 刘宏亮, 等. 基于网格传输网络模型的高频纳秒脉冲串作用下单细胞穿孔特性仿真[J]. 电工技术学报, 2018, 33(18): 41-54. Mi Yan, Xu Jin, Liu Hongliang, et al.Simulation on perforation features in a single-cell system exposed to high-frequency nanosecond pulse bursts based on mesh transport network model[J]. Transactions of China Electrotechnical Society, 2018, 33(18): 41-54. [6] Bos W V D, Scheltema M J, Siriwardana A R, et al. Focal irreversible electroporation as primary treatment for localized prostate cancer[J]. BJU International, 2017, 119(2): 37-38. [7] 米彦, 孙才新, 姚陈果, 等. 基于等效电路模型的细胞内外膜跨膜电位频率响应[J]. 电工技术学报, 2007, 22(6): 6-11. Mi Yan, Sun Caixin, Yao Chenguo, et al.Frequency response of transmembrane potential on cell inner and outer membrane based on equivalent circuit model[J]. Transactions of China Electrotechnical Society, 2007, 22(6): 6-11. [8] 姚陈果, 吕彦鹏, 赵亚军, 等. 基于能量概率与微孔力模型的脉冲电场对细胞电穿孔动态过程的仿真分析[J]. 电工技术学报, 2016, 31(23): 141-149. Yao Chenguo, Lu Yanpeng, Zhao Yajun, et al.Simulation analysis of dynamic process of cell electroporation based on energy probability and microporous force model[J]. Transactions of China Electrotechnical Society, 2016, 31(23): 141-149. [9] Onik G, Mikus P, Rubinsky B.Irreversible electroporation: implications for prostate ablation[J]. Technology in Cancer Research & Treatment, 2007, 6(4): 295-300. [10] Rubinsky J, Onik G, Mikus P, et al.Optimal parameters for the destruction of prostate cancer using irreversible electroporation[J]. The Journal of Urology, 2008, 180(6): 2668-2674. [11] Martin R C G, Mcfarland K, Ellis S, et al. Irreversible electroporation in locally advanced pancreatic cancer: potential improved overall survival[J]. Annals of Surgical Oncology, 2013, 20(3): 443-449. [12] Charpentier K P, Wolf F, Noble L, et al.Irreversible electroporation of the pancreas in swine: a pilot study[J]. International Hepato-Pancreato-Biliary Association, 2010, 12(5): 348-351. [13] Wendler J J, Pech M.Urinary tract effects after multifocal nonthermal irreversible electroporation of the kidney: acute and chronic monitoring by magnetic resonance imaging, intravenous urography and urinary cytology[J]. Cardiovascular & Interventional Radiology, 2012, 35(4): 921-926. [14] Olweny E O, Kapur P, Tan Y K, et al.Comparison of nonthermal irreversible electroporation (NT-IRE) to thermal irreversible electroporation (T-IRE) for kidney ablation in a porcine model[J]. Journal of Endourology, 2011, 25(1): A4-A4. [15] Tracy C R, Kabbani W, Cadeddu J A .Irreversible electroporation (IRE): a novel method for renal tissue ablation[J]. Journal of Urology, 2011, 183(4): 286-287. [16] Calmels L, Al-Sakere B, Ruaud J P, et al.In vivo MRI follow-up of murine tumors treated by electrochemotherapy and other electroporation-based treatments[J]. Technology in Cancer Research & Treatment, 2012, 11(6): 561-570. [17] 米彦, 彭文成, 芮少琴, 等. 高频纳秒脉冲串作用下皮肤肿瘤热效应的多参数有限元仿真与实验[J]. 电工技术学报, 2017, 32(22): 264-274. Mi Yan, Peng Wencheng, Rui Shaoqin, et al.Thermal effects in skin tumor exposed to high-frequency nanosecond pulse bursts: multi-parametric finite element simulation and experiment[J]. Transactions of China Electrotechnical Society, 2017, 32(22): 264-274. [18] Wong D, Lee E W, Kee S T.Translational research on irreversible electroporation: VX2 rabbit head and neck[M]. Clinical Aspects of Electroporation, 2011. [19] 郭飞, 李成祥, 唐贤伦, 等. 冲激辐射天线实现皮秒脉冲电场在人体大脑模型中聚焦的研究[J]. 电工技术学报, 2016, 31(3): 195-202. Guo Feng, Li Chengxiang, Tang Xianlun, et al.Focusing of picosecond pulsed electric field in human brain model with impulse radiating antenna[J]. Transactions of China Electrotechnical Society, 2016, 31(3): 195-202. [20] Lee E W, Chen C, Prieto V E, et al.Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation[J]. Radiology, 2010, 255(2): 426-433. [21] Xiong Zhengai.Percutaneous ultrasound-guided irreversible electroporation: a goat liver study[J]. Oncology Letters, 2012, 4(3): 450-454. [22] Appelbaum L, Bendavid E, Sosna J, et al.US findings after irreversible electroporation ablation: radiologic-pathologic correlation[J]. Radiology, 2012, 262(1): 117-125. [23] Hsiao C Y, Huang K W.Irreversible electroporation: a novel ultrasound-guided modality for non-thermal tumor ablation[J]. Journal of Medical Ultrasound, 2017, 25(4): 195-200. [24] Sommer C M, Fritz S, Vollherbst D, et al.CT-guided irreversible electroporation in an acute porcine liver model: effect of previous transarterial iodized oil tissue marking on technical parameters, 3D computed tomographic rendering of the electroporation zone, and histopathology[J]. Cardio Vascular and Interventional Radiology, 2015, 38(1): 191-200. [25] Figini M, Wang Xifu, Lyu T, et al.Preclinical and clinical evaluation of the liver tumor irreversible electroporation by magnetic resonance imaging[J]. American Journal of Translational Research, 2017, 9(2): 580-590. [26] Martin R C.Irreversible electroporation of locally advanced pancreatic head adenocarcinoma[J]. Journal of Gastrointestinal Surgery, 2013, 17(10): 1850-1856. [27] Campelo S, Valerio M, Ahmed H U, et al.An evaluation of irreversible electroporation thresholds in human prostate cancer and potential correlations to physiological measurements[J]. APL Bioengineering, 2017, 1(1): 1-10. [28] Ivorra A, Mir L M, Rubinsky B.Electric field redistribution due to conductivity changes during tissue electroporation: experiments with a simple vegetal model[J]. Ifmbe Proceedings, 2009, 25(13): 59-62. [29] Yao Chenguo, Lü Yanpeng, Dong Shoulong, et al.Irreversible electroporation ablation area enhanced by synergistic high- and low-voltage pulses[J]. Plos One, 2017, 12(3): 1-19. [30] Hjouj M, Rubinsky B.Magnetic resonance imaging characteristics of nonthermal irreversible electroporation in vegetable tissue[J]. Journal of Membrane Biology, 2010, 236(1): 137-146. [31] Bhonsle S P, Arena C B, Daniel C S.Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses[J]. BioMedical Engineering OnLine, 2015, 14(S3): 1-14. [32] Zupanic A, Kos B, Miklavcic D .Treatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation[J]. Physics in Medicine and Biology, 2012, 57(17): 5425-5440. [33] Muratori C, Pakhomov A G, Shu X, et al.Electrosensitization assists cell ablation by nanosecond pulsed electric field in 3D cultures[J]. Scientific Reports, 2016, 6(1): 1-9.
2020, Vol. 35 
