The Simulation and Experiment of Magneto-Motive Ultrasound Imaging Based on Time Reversal Method
Zhang Shuai1,2, Li Zixiu1,2, Zhang Xueying1,2, Zhao Mingkang1,2, Xu Guizhi1,2
1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Electrical Engineering Hebei University of Technology Tianjin 300130 China; 2. Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province School of Electrical Engineering Hebei University of Technology Tianjin 300130 China
Abstract Magnetic nanoparticles can specifically bind to the tumor, which has great significance and potential application prospects for early diagnosis or specific diagnosis of tumors. This paper presents a magneto-motive ultrasound imaging method based on the time reversal method. Herein, magneto-motive force is produced by a time-varying magnetic field to induce ultrasound in the magnetic nanoparticles labeled tissue, and an image of nanoparticles distribution is reconstructed. In this paper, the finite element method was used to establish nanoparticles labeling biological tissue models with different radii. The acoustic pressure signals of magneto-motive ultrasound were obtained by calculation and simulation. The nanoparticles distribution images were reconstructed based on the time inversion method. The biological tissue imitation models and fresh vitro biological tissue samples were built with labeled nanoparticles. The magneto-motive ultrasound imaging experiments were performed. The simulation and experimental results show that the consistency of nanoparticles distribution image boundary and the nanoparticles boundary of labeling biological tissue is higher. The imaging method can quickly and accurately obtain the size and position information of the imaging targets, which indicates that the effectiveness of the proposed method and provides a promising tool for magnetic nanoparticle-labeled biological tissues in molecular imaging.
Zhang Shuai,Li Zixiu,Zhang Xueying等. The Simulation and Experiment of Magneto-Motive Ultrasound Imaging Based on Time Reversal Method[J]. Transactions of China Electrotechnical Society, 2019, 34(16): 3303-3310.
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2019, Vol. 34 
