面向临床多针消融肿瘤的不可逆电穿孔量效关系模型

doi:10.19595/j.cnki.1000-6753.tces.190470

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Abstract In the clinical application of irreversible electroporation tumor therapy, because the ablation area generated by the electric field pulse is small, multi-electrode treatment need to achieve complete ablation of tumor tissue for patients with large tumor size. However, at present, multi-needle treatment is still predicted by the superposition of two treatment effects, which is not conducive to the development of an accurate treatment-planning. Aiming at this problem, based on the electric field distribution and ablation effect of irreversible electroporation tumor ablation with multi-electrode, a numerical model suitable for multi-electrode treatment is established. Based on analysis of the conductivity model, a dose-effect relationship model considering the cumulative effect under multi-needle treatment was established. The potato tissue ablation experiment was performed under the voltage of 500V, 600V, 700V, 800V and 1 000V, and compared the prediction results of the traditional model, the superposition model and the dose-response model. The results show that the accuracy and feasibility of the dose-response model (mean error is less than 5.04%), and it can be used for pre-treatment of multi-needle treatment guidance, providing theoretical and data support for the development of treatment options for clinical applications of irreversible electroporation.

Key words： Cumulative effect dose-effect relationship model treatment plan irreversible electroporation ablation effect

Received: 22 April 2019

PACS:	TM11
	TM836
	Q64

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	Yao Chenguo
	Zheng Shuang
	Liu Hongmei
	Tang Xiao
	Dong Shoulong

Cite this article:

Yao Chenguo,Zheng Shuang,Liu Hongmei等. Model of Irreversible Electroporation Dose-Effect Relationship for Clinical Multi-Needle Ablation Tumors[J]. Transactions of China Electrotechnical Society, 2020, 35(11): 2491-2498.

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https://dgjsxb.ces-transaction.com/EN/10.19595/j.cnki.1000-6753.tces.190470 OR https://dgjsxb.ces-transaction.com/EN/Y2020/V35/I11/2491

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