大气压低温等离子体射流制备刺激响应型凝胶

doi:10.19595/j.cnki.1000-6753.tces.201459

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摘要利用大气压低温等离子体射流直接处理甲基丙烯酸-2-羟乙酯（HEMA）与甲基丙烯酸二乙氨基乙酯（DEAEMA）单体的混合液从而得到刺激响应型凝胶。这种等离子体聚合凝胶的产生无需偶联剂或引发剂。X射线光电子能谱仪（XPS）分析结果表明这种等离子体聚合凝胶保留了两种单体的功能团。接触角和表面能的测量计算说明这种凝胶具有可稳定保持的亲水性。电阻抗谱分析显示这种凝胶具有可逆pH响应特性。体外细胞毒性实验证明凝胶具有良好的生物相容性和安全性,可以显著增强骨肉瘤细胞MG63的贴附和增殖。

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关键词 ：大气压低温等离子体射流, 刺激响应型凝胶, 电阻抗谱, 生物相容性

Abstract：An atmospheric plasma jet (APPJ) was used to directly treat the mixture of (hydroxyethyl) methacrylate (HEMA) and 2-(diethylamino)ethyl methacrylate (DEAEMA) monomers to get stimuli-responsive hydrogels. The fabrication of plasma polymerized HEMA-co-DEAEMA (PPHD) hydrogels did not need crosslinkers or initiator agents. Analysis of X-ray photoelectron spectroscopy (XPS) revealed that PPHD hydrogels inherited functionalities of individual monomers. The calculation of the contact angle and surface energy indicated that PPHD hydrogels are hydrophilic. Impedance spectroscopy for PPHD hydrogels in different pH solutions revealed a reversible pH-response manner. In vitro cytotoxicity test showed a good biocompatibility for PPHD hydrogels, which could significantly enhance the adhesion and proliferation of osteoblast cells (MG-63).

Key words： Atmospheric plasma jet stimuli-responsive hydrogels impedance spectroscopy biocompatibility

收稿日期: 2020-10-30

PACS:	O539
	TM934.73

通讯作者: 庄杰男,1980年生,研究员,博士生导师,研究方向为脉冲功率与低温等离子体的生物医学与环境应用。E-mail：jzhuang@sibet.ac.cn

作者简介: 石富坤男,1988年生,助理研究员,研究方向为脉冲功率与低温等离子体生物医学效应及诊断技术。E-mail：shifkscu@foxmail.com

引用本文:

石富坤, 郭雨怡, 王群, JuergenF.Kolb, 庄杰. 大气压低温等离子体射流制备刺激响应型凝胶[J]. 电工技术学报, 2021, 36(15): 3147-3153. Shi Fukun, Guo Yuyi, Wang Qun, Juergen F. Kolb, Zhuang Jie. Polymerization of Stimuli-Responsive Hydrogels by Using a Cold Atmospheric Plasma Jet. Transactions of China Electrotechnical Society, 2021, 36(15): 3147-3153.

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https://dgjsxb.ces-transaction.com/CN/10.19595/j.cnki.1000-6753.tces.201459 https://dgjsxb.ces-transaction.com/CN/Y2021/V36/I15/3147

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